Lemongrass: Pops open Apoptosis
Farnesol is found in lemon grass and is a natural compound that is the building block of most sesquiterpenoids (a large and varied class of organic compounds – usually resinous and aromatic in nature found in plants).
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“Evidence suggests that Farnesol can inhibit tumorigenesis and that it is a chemopreventative and anti-tumor agent in vivo.”
Farnesol, found in plants such as Lemon Grass, has been implicated in a number of biochemical and cellular processes.
- Regulation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and CTP:
- Phosphocholine cytidylyltransferase α (CCTα), the rate limiting enzymes in the mevalonate pathway
- Phosphatidylcholine biosynthesis, respectively, and the generation of reactive oxygen species.
- Activation of the MEK1/2-ERK1/2 pathway
- Activation of the NF-κB signaling pathway and a number of NF-κB target genes
Recent studies have also indicated that farnesol can induce apoptosis in lung carcinoma cells. The review provides an overview of the biochemical and cellular processes regulated by farnesol in relationship to its growth-inhibitory, apoptosis-promoting, and anti-tumor effects.