Growth inhibition of Colorectal Cancer Cells by Green Tea Polyphenols
Green Tea is in the scientific press again due to its health benefits. Epigallocatechin-3-gallate (EGCG), the major component of Green Tea has been shown previously to induce apoptosis and cell cycle arrest in cancer cells. To date, the detailed mechanisms of action were not fully understood.
Zhang et al, studied molecular targets of EGCG in human colorectal cancer cells.
They observed that certain specific markers were down-regulated or up-regulated which enabled them to elucidate the mechanism of EGCG on anti-cancer benefits.
The data shown by the researchers elucidates a mechanism by which EGCG inhibits cell growth of colorectal cancer cells.
EGCG-induced cyclin D1 degradation and p21 transcriptional activation partially contribute to growth suppression in these cells.
Green Tea is used a base ingredient in The Wise Herb Company health drinks.