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Can licorice lick colon cancer?

December 8, 2010

An interesting discussion here from Stewart & Prescott on how certain compounds in Liquorice could be effective in reducing tumour growth.
COX-2 promotes colon cancer. Selective COX-2 inhibitors can therefore reduce disease but their side effects limit their therapeutic use. In this issue of the JCI, Zhang et al. used gene silencing and a derivative of licorice root to show that inhibition of the enzyme 11beta-hydroxysteroid dehydrogenase type II(11betaHSD2) reduces tumor COX-2 activity, tumor growth, and metastasis.

 

See also: Johnson et al.

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