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More evidence of Green Tea antioxidant, anti-inflammatory activity!

June 7, 2011
Source: Free Radic Biol Med. 2011 May 23


Summary

Tsai et al have recently shown the anti-inflammatory effects of green tea Catechin (epigallocatechin-3-gallate (EGCG))
by inhibiting nuclear factor-kappa B (NF-κB)-mediated inflammatory responses (lupus nephritis in animal model systems
).

They found that EGCG (1) prevented renal function impairment, and severe renal lesions; (2) increased renal nuclear factor E2-related factor 2 (Nrf2) and glutathione peroxidase activity; (3) reduced renal oxidative stress, NF-κB activation, and NLRP3 mRNA/protein expression and protein levels of mature caspase-1, IL-1β, and IL-18; and (4) enhanced splenic regulatory T (Treg) cell activity.

Their research clearly demonstrate that EGCG has preventative effects on lupus nephritis in animal model systems.  This is associated with enhancing effect on an antioxidant signaling pathway, decreasing inflammasome, and increasing T cell activity.

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