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Licorice components modulate inflammatory response

June 9, 2011


The roots and rhizomes of licorice (Glycyrrhia) or liquorice species are used in alternative medicine and is a key ingredient in InnOrbit drink products.

The investigation looked at the anti-inflammatory effects of licorice components glycyrrhizic acid (GA) and 18β-glycyrrhetinic acid (18βGA) in a model system. The results showed that treatments GA or 18βGA did not reduce cell viability but did significantly inhibit the production of LPS-induced nitric oxide (NO), prostaglandin  and reactive oxygen species.

GA and 18βGA:

  • Significantly reduced the protein and mRNA levels of iNOS and COX-2 in LPS-induced macrophages.
  • Inhibited the activation of NF-κB, and the activities of PI3K p110δ and p110γ isoforms.
  • Reduced the production of LPS-induced TNF-α, IL-6, and IL-1β in a dose-dependent manner.

“Results suggest that GA and 18βGA may provide an anti-inflammatory effect by moderating the generation of excessive NO, PGE2, and ROS and by suppressing the expression of proinflammatory genes through the inhibition of NF-κB and PI3K activity.

GA and 18βGA (licorice components) might serve as potential agents for the treatment of inflammatory-mediated diseases.”

More detailed information can be found HERE.

Licorice is a key ingredient in the InnOrbit functional drinks:

UP&GO, SLIM&FIT, CALM&RELAX, and YOUNG&FUN. Also check out the ingredients in the InnOrbit Energy Booster Shots

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