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Potential anti-inflammation & anti-apoptosis properties of Amla (Emblica officinalis)

October 27, 2011

Amla (Emblica officinalis Gaertn.), a natural ayurvedic ingredient, is rich in vitamin C, gallic acid, flavonoids, and tannins, which may protect against organ injury. For example, it is known that inflammation and oxidative stress contribute to liver injury. In traditional medicine Emblica officinalis is also traditionally used for central nervous system disorders.

In an animal study reported in the Journal of Medicinal Food,  Chen et al elucidated the effects of Amla induced injury by evaluating reactive oxygen species (ROS) responses in the liver and bile.  Amla was shown to be more effective than vitamin C in scavenging O₂⁻·, hydrogen peroxide, and nitric oxide.  They suggest that Amla counteracts N-nitrosodiethylamine-induced liver injury via its antioxidant, anti-inflammation, anti-apoptosis, and anti-autophagy properties.

In another study Golechha et al, studied the neuroprotective effects of Amla extracts against induced seizures using kainic acid (KA).

They demonstrated in animal model systems that Amla increased the latency of seizures as compared with the vehicle-treated KA group. Amla also attenuated the KA induced increase in the TNF-α level in the brain and improved the cognitive deficit induced by KA, as evidenced by increased latency in passive avoidance task.  They concluded that Amla extracts were  effective in suppressing KA-induced seizures, cognitive decline, and oxidative stress in the brain. These neuroprotective effects may be due to the antioxidant and anti-inflammatory effects of compounds of Amla.

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