Green Tea and Alzheimer’s Disease Therapy
Lopez Del Amo et al, studied the green tea compound epigallocatechin-3-gallate (EGCG). They demonstrated that it can inhibit Alzheimer’s disease β-amyloid peptide (Aβ) neurotoxicity.
They demonstrated that EGCG-induced Aβ oligomers to adopt a well-defined structure and interferes with the aromatic hydrophobic core of Aβ.
The structural analysis of small-molecule-induced amyloid aggregates potentiates drug development for Alzheimer’s disease therapies.