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Recent Research on Green Tea: Diabetes, Neuroprotection, Anticancer… & more

February 18, 2012

Green Tea is the one of the most researched natural ingredients. Recently, Zhang, et al (in the Journal of Functional Foods.) studied the Effects of catechin-enriched green tea beverage on fat loss in adults in a double-blind, placebo-controlled, randomized trial. The data adds to an ever-growing proof that green tea can support weight management.

We have seen before its multi-functional properties and below we summarise the most recent research findings:

  • Study 1

Diet supplementation with green tea extract (epigallocatechin gallate) in an animal model was studied by Ortsater, et al.

Green tea was suggested as a therapeutic agent for the treatment of diabetes decades ago but it is only recently when more compelling evidence has been revealed about its antidiabetic properties. Ortsater and co-workers determined Glucose and insulin levels in an animal model after feeding with Green Tea extracts.

This study shows that the green tea extract catechins preserve islet structure in the pancreas and enhances glucose tolerance in genetically diabetic cells. Consumption of catechins could therefore contribute to nutritional strategies for the prevention and treatment of type 2 diabetes.

In similar research by Yan et al, demonstrated that Green tea catechins ameliorates Adipose Insulin Resistance by Improving Oxidative Stress.

Adipose (Fat tissue) oxidative stress may have a central role in causing insulin resistance, according to recent findings. The objective of this study was to elucidate a new mechanism for green tea’s anti-insulin resistance effect. In an animal study Green tea catechins (GTCs) significantly decreased glucose levels and increased glucose tolerance in an animal model system. Green tea catechins like EGCG could improve adipose insulin resistance, and provide a positive effect on “mopping up” Reactive Oxidative Species.

The effect of green tea extract on body weight, serum levels of glucose, and lipids in a streptozotocin-induced animal model were investigated by Haidari, et al.

Administration of green tea extract caused a significant decrease in serum glucose and total cholesterol levels and significantly improved the body weight

It appears that green tea extract has both anti-hyperglycemic and hypocholesterolmic effects in diabetic model systems.

  • Study 2

In two separate previous studies, a team at the School of Pharmaceutical Sciences, University of Geneva, reported that subcutaneous or oral administration of (-)-epigallocatechin-3-gallate (EGCG) limited the development of muscle degeneration in an animal model with Duchenne muscular dystrophy (DMD). The efficacy of EGCG for limiting the development of dystrophic muscle lesions in suggests that EGCG may be of benefit for DMD patients.

  • Study 3

The Anti-Cancer effects of Green Tea were studied by Ren et al, in Myeloma:

The Green tea catechin EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. The data from this study suggest that peroxiredoxin V is a key target via which EGCG mediates its anticancer effects (Myeloma). Peroxiredoxin is an antioxidant enzyme that also controls cytokine-induced peroxide levels and mediate signal transduction in mammalian cells.

What is Myeloma? Normally, new plasma cells are produced to replace old, worn-out cells in an orderly, controlled way. However, in myeloma the process gets out of control and large numbers of abnormal plasma cells (myeloma cells) are produced. These fill up the bone marrow and interfere with the production of normal white cells, red cells and platelets.

  • Study 4

Results obtained by Tyring (University of Texas, Health Science Center) indicate that sinecatechins specifically inhibit multiple human papillomavirus-induced pathways and molecules via direct antiviral activity. Catechins inhibit a broad range of enzymes and kinases involved in the generation of inflammatory mediators: proteases, oxygenases, and protein kinases.

Have a cuppa!

  • Study 5

Research by Hou et al, indicated that Green Tea compounds provide neuroprotective effects against excitotoxins and may have a clinical application in epilepsy.

Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters and similar substances.


Green Tea is used as a base in the InnOrbit Functional Infusion Range!

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