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Lemongrass component: antiinflammatory & analgesic against pain

February 25, 2012

Citronellol was studied by Brito et al,  for its antinociceptive (reduces sensitivity to painful stimuli) and anti-inflammatory properties in an animal model.

Citronellol is a monoterpene alcohol, and is a naturally occurring monoterpene compound common in essential oils of plants like Lemongrass  (Cymbopogon citratus).

Pretreatments with Citronellol showed that it could inhibit both neutrophil infiltration and the increase in TNF-α levels.  In in vitro experiments, demonstrated that Citronellol could decrease nitric oxide production.

Together, the above results indicate that Citronellol is effective as an analgesic compound in various pain models, with its action probably mediated by the inhibition of peripheral mediators as well as central inhibitory mechanisms that could be related to its strong antioxidant effect.


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