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Isoliquiritigenin Isolated from Liquorice Prevents Apoptosis in Neurons

March 28, 2012

Liquorice is a popular medicinal herb containing antioxidative and anti-inflammatory bioactive components.

The effects of liquorice against Parkinson’s disease cell death were investigated with focus on Isoliquiritigenin (ISL) a key component of liquorice.

These results provide the first evidence that Isoliquiritigenin can protect dopaminergic cells under oxidative stress conditions by regulating the apoptotic process.

Dopaminergic cells are collections of neurons in the central nervous system that contain the neurotransmitter dopamine.


Hwang et al,
Bioscience, biotechnology, and biochemistry (Mar 27, 2012)

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