Green Tea: Synergistic effect on Cancer Inhibition
Prostaglandin and its analogs are a large series of hormones which can enhance cancer development and progression, acting as cocarcinogens or tumor promoters, and have profound effects on carcinogenesis.
In order to overcome adverse effects lower doses of prostaglandin inhibitors (which can have various side effects) the investigators (Härdtner et al, 2012) in this study applied them in combination with other agents exhibiting complementary effects.
In this study Prostaglandin inhibitors in combination with green tea-derived catechin (-)-epigallocatechin-3-gallate (EGCG) were studied on the expression of interleukin (IL)-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.
The investigators found that EGCG synergistically diminished metabolic activity via apoptosis induction. They conclude that Green Tea EGCG synergistically boosts Prostaglandin-Inhibitor effects and reduces the levels needed to elicit beneficial effects on tumorigenic mediators by a factor of ten.