Liquorice, Amorfrutins and Diabetes
Studies by Weidner et al, showed that amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity.
These results show that selective PPARγ-activation by diet-derived ligands may constitute a promising approach to combat metabolic disease.
PPARγ is a nuclear receptor (peroxisome proliferator-activated receptor gamma) that plays a central role in lipid and glucose metabolism.
Published online before print April 16, 2012, doi: 10.1073/pnas.1116971109 PNAS April 16, 2012