Green Tea and Diabetes
A study by Faria et al, focused on the potential of Green Tea to improve uncoupling of endothelial nitric oxide synthase (eNOS) in diabetic conditions. The results of their studies suggest that Green Tea reversed the diabetes-induced oxidative stress in diabetes and helped to ameliorate Nitric Oxide levels.
Nitric oxide (NO·) is an important protective molecule in the veins and arteries. NO· synthase (eNOS) is responsible for most of the vascular NO· produced in the walls of arteries. Cardiovascular risk factors such as hypertension, hypercholesterolemia, diabetes mellitus, or chronic smoking stimulate the production of reactive oxygen species in the vascular wall. A transformation of eNOS from a protective enzyme to a contributor to oxidative stress has been observed in several models of cardiovascular risk factors.
“A major weapon of endothelial cells to fight vascular disease is endothelial nitric oxide synthase (eNOS), an enzyme that generates the vasoprotective molecule nitric oxide (NO·). However, many of us unintentionally mistreat our endothelial cells. We expose them to risk factors such as cigarette smoke, high blood pressure, high glucose, or high lipids. Despite this abuse, our endothelium bears with us for some time, tries to maintain NO· production, and preserves vascular protection. However, the risk factors lead to excess production of superoxide (O2·−; ie, they produce oxidative stress). O2·− reacts with NO· to form peroxynitrite, and vascular protection slowly vanishes.”
It appears Green Tea may have an important role in reducing risk factors in several chronic diseases including diabetes.
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace