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Synergy research: A new generation of phyto-pharmaceuticals?

May 22, 2012

The successful use of herbal drug combinations in traditional medicine and their therapeutic success to treat many illnesses and maintain  health is becoming interesting to scientists.

There are many examples of multi-extract combinations used presently, which exhibit synergistic efficiency based on multi-target mechanisms of action.

Among the natural products, gallocatechins of green tea and curcuminoids of ginger are the presently favoured polyphenols for a possible future use in co-medication with antibiotics and standard anticancer drugs.

The main targets reported by Wagner were found to be COX 1+2, NF-κB, and membrane glycoproteins that belong to the ATP-binding cassette (ABC) transporter family.

Previous Research Reported:

Quercetin is a bio-active component found in many natural herbs and plants like Neem (Azadirachta indica).

On this website we have seen several studies that propose that combinations of herbs are more effective in chronic disease therapies than isolated doses.

A study by Wang et al, has demonstrated a similar synergistic effect between Quercetin and Green Tea catechins (EGCG).

Quercetin combined with Green Tea EGCG in vitro demonstrated enhanced inhibition of cell proliferation.

The investigators state that: “Quercetin of Neem (Azadirachta indica) and EGCG in combination synergistically inhibited cell proliferation, caused cell cycle arrest, and induced apoptosis in Prostate Cancer cells“.

This gives some support to the Holistic approach needed (and supported by InnOrbit products) and that combinations of herbs may be more effective than ‘Single’ isolated doses of plants and/or their components.

1+1 = 3; or Synergy between herbs & spices is better:

  •  Multi Herbal mixtures have a more potent antioxidant activity than single doses.  A 2nd paper shows that whole extract of Hibiscus (minus fibres etc.) is more potent than pure Hibiscus isolates.

Ayurvedic doctors were already developing this synergistic approach with herbal remedies many hundreds of years ago to maintain health and prevent diseases

Cardiovascular diseases, cancer, arthritis and similar are caused by free radicals produced by metabolic pathways.

Many plants like Cinnamomum cassia and Camellia sinensis Linn. have been researched with respect to their antioxidant properties.

The researchers study was performed to corroborate the hypothesis that formulation of a poly-herbal combination shows a synergistic effect with green tea.

The research results suggest that a combination of all these herbs with green tea can synergistically enhance antioxidantactivity and thus lower doses of each herb with green tea may be used.

Studies showed that individual herbs have significant amounts of phenolics and flavonoids and their polyherbal combination with green tea was found to produce best antioxidant activity among all individual extracts.”

We suspect that Ayurvedic doctors probably knew this already!

Great news for InnOrbit infusion drinkers!

Wang, et al. Nutrition and cancer (Mar 28, 2012).

Full paper abstract and link can be found HERE

Jain et al, J Adv Pharm Technol Res. 2011 Jul;2(3):177-83.

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