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YOUNG&FUN Natural ingredients and Neuro-protection

May 26, 2012

Dr. Domenico Pratico (Temple University, USA) has shown in various research studies that oxidative damage in the brain precedes amyloid plaques in Alzheimer’s that ultimately destroy brain cells. The main area affected is the hippocampus, followed by the frontal and temporal lobes of the brain – which can lose from 30 to 40% of their neurons via the progression of this disease.

Oxidation seems to be the issue in Alzheimer’s. In model systems there is 25% more oxidative damage in the diseased brains compared to normal non-diseased brains. This keeps increasing until it is 100% higher at 10 or 11 months.  At 12 months, oxidative damage is 200% higher.

Dr. Nick Fox at the University College in London demonstrated that brain degeneration was observed about three years before clinical symptoms of the disease appeared.

Oxidative damage therefore seems to be occurring before any disease manifests itself. And research indicates that oxidative stress is probably a primary event in the course of illnesses in the brain, particularly Alzheimer’s.


So could Antioxidants found in Herbs & Spices used in health drinks like YOUNG&FUN help to prevent or reduce oxidative damage in the brain?

There are encouraging results from studies demonstrating the multi-mechanistic neuroprotective properties of many naturally occurring compounds including Herbs & Spices. Similarly, there are some intriguing clinical observational studies that potentially suggest both acute and chronic neuro-protective effects.

Among the bio-active ingredients used by The Wise Herb Company, and implicated in Brain Health, are

  • Green tea

Catechins could help with memory (animal model), recovery from brain injury and Alzheimer’s.

  • Mint

Neuro-protective effects of mint compound have been demonstrated.

  • Centella asiatica – Pennywort

Clinical studies have demonstrated that Centella (Pennywort) can improve mental ability and agility.

  • Liquorice

Glycyrrhiza glabra (Licorice/Liquorice): could slow down cognitive impairment and enhance memory.


Intuitively, it makes sense since these Herbs & Spices are packed with antioxidants and YOUNG&FUN could potentially help in the protection against oxidative stress in the brain!

“It was believed that amyloid fibrils – rope-like structures made up of proteins sometimes known as fibres – are inert, but that there may be toxic phases during their formation which can damage cells and cause disease. Scientists at the University of Leeds have shown that amyloid fibres are in fact toxic – and that the shorter the fibre, the more toxic it becomes.

“This is a major step forward in our understanding of amyloid fibrils which play a role in such a large number of diseases,” said Professor Sheena Radford of the Astbury Centre for Structural Molecular Biology and the Faculty of Biological Sciences. “We’ve revisited an old suspect with very surprising results. Whilst we’ve only looked in detail at three of the 30 or so proteins that form amyloid in human disease, our results show that the fibres they produce are indeed toxic to cells especially when they are fragmented into shorter fibres.”

Amyloid deposits can accumulate at many different sites in the body or can remain localised to one particular organ or tissue, causing a range of different diseases. Amyloid deposits can be seen in the brain, in diseases such as Parkinson’s and Alzheimer’s, whereas in other amyloid diseases deposits can be found elsewhere in the body, in the joints, liver and many other organs. Amyloid deposits are also closely linked to the development of Type II diabetes.”

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