Azadirachta indica (Neem): Useful for the treatment of Diabetes
Neem (Azadirachta indica) is used extensively in herbal treatments, and is a key ingredient in The Wise Herb Company herbal drinks, has been reported to contain a α-glucosidase (glucose degrading enzyme) inhibitor by Mukherjee & Sengupta. They characterized the inhibitor as nimbidiol (a diterpenoid), present in root and stem-bark of the tree.
This Nimbidiol inhibited intestinal (mammalian): maltase-glucoamylase, sucrase-isomaltase, lactase, trehalase and fungal α-glucosidases.
Development of nimbidiol as an anti-diabetic drug appears to be promising because of broad inhibition spectrum of intestinal glucosidases (sugar degrading enzymes).