Gingerols of Ginger: Enhance Glucose Uptake
In a study by Li et al, they investigated the active constituents of the rhizome of Ginger (Zingiber officinale), and evaluated its activity on glucose uptake in model systems.
The effect of the extract, fractions, and purified compounds on glucose uptake were evaluated and it was shown that the pungent phenolic gingerol constituents were identified as the major active compounds in the ginger extract enhancing glucose uptake.
The activity of (S)--gingerol was found to be associated primarily with an increase in surface distribution of GLUT4 protein on the L6 myotube plasma membrane, as detected by expression of hemaglutinin epitope-tagged GLUT4 in L6 muscle cells.
The enhancement of glucose uptake in model animal systems suggests that gingerol, a principle component of Ginger, supports the potential of ginger for the prevention and management of hyperglycemia and type 2 diabetes.