Centella asiatica (Pennywort): Immunity & Arthritis protection
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Centella asiatica (Pennywort) contains a series of terpenes (oils), the most common of which is called Madecassoside. In Asia, Centella asiatica is used for wound healing and scar management. Liu et al investigated the therapeutic potential and underlying mechanisms of madecassoside on induced arthritis in an animal model.
The Pennywort “oil” was orally administered from the day of the antigen challenge for twenty consecutive days, dose-dependently alleviated the severity of the disease based on the reduced clinical scores, and elevated body weights.
They conclude that madecassoside substantially prevented induced arthritis, and this component is the major active constituent of Centella asiatica responsible for clinical uses for rheumatoid arthritis.
The underlying mechanisms of action may be through regulating the abnormal humoral and cellular immunity as well as protecting joint destruction.