Antitumor activity of Green Tea polyphenol
A study by Lemarié et al, focussed on thetherapeutic potential of epigallocatechin-3-gallate (EGCG), a Green Tea polyphenol, for its anticancer properties. The aim of this study was to determine whether a tumor-targeted vesicular formulation of EGCG would suppress the growth of carcinoma and melanoma in vitro and in vivo in a model study system.
The intravenous administration of EGCG encapsulated in transferrin-bearing vesicles resulted in tumor suppression in 40% of various tumours. The results suggest that Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.