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Liquorice: reduction of cellular damage and oxidative stress

August 22, 2012

Liquorice (Glycyrrhiza glabra) is a widely used medicinal plant in many traditional cultures and medicines like Ayurveda. Work by Sakr & Shalaby investigated the effect of licorice aqueous extract on toxicity in an animal model. Carbendazim is a toxic agent that can induce various factors like degeneration and loss of apoptosis. Compounds like malondialdehyde (MDA) a marker of lipid peroxidation, and supersuperoxide dismutase (SOD) and catalase (CAT) were also elevated.

 

Co-administration of liquorice extract with carbendazim improved the histomorphological and histopathological changes. The results from this study suggest that liquorice could improve the cellular toxicity of carbendazim and this effect may be attributed to antioxidant properties of one or more of its constituents.

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