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Garcinia: Anti-Obesity and Safe levels

September 3, 2012

Obesity is now recognised as a widespread chronic diseases and is associated with health disorders such as heart attack, high blood pressure & diabetes. Garcinia or more specifically hydroxycitric acid (HCA) extracted from Garcinia is among many natural products used against obesity and to help weight control.


HCA suppresses the feeling of hunger by increasing the release/availability of serotonin, a neurotransmitter that regulates eating behavior and appetite control. It had also been reported that HCA decreases serum leptin in mice and humans, as well as expression level of abdominal fat leptin in rats.

The evaluation of the potential toxicity of weight control supplement was investigated by Chua et al. The structure, mechanism of action, long history of the use of Garcinia/HCA and comprehensive scientific evidence had shown “no observed adverse effect level, at levels up to 2800 mg/day, suggesting its safety for use.

The levels of HCA in the The Wise Herb Company infusion SLIM&FIT are well below this level.

Further Reading:

Ohia SE, Awe SO, LeDay AM, Opere CA, Bagchi D. Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Research Communications in Molecular Pathology and Pharmacology.2001;109(3-4):210–216.

 Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX) Molecular and Cellular Biochemistry.2002;238(1-2):89–103.

 Hayamizu K, Hirakawa H, Oikawa D, et al. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia. 2003;74(3):267–273.

 Preuss HG, Bagchi D, Bagchi M, Rao CVS, Dey DK, Satyanarayana S. Effects of a natural extract of (−)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes, Obesity and Metabolism. 2004;6(3):171–180.

 Roy S, Rink C, Khanna S, et al. Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expression. 2004;11(5-6):251–262.

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