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Traditional Herbs & Spices in ischemia-reperfusion injury

September 3, 2012

Brosková et al investigated the potential protective effect of selected natural substances in an animal model of heart and ischemia-reperfusion (I/R).


It is known that I/R induces an inflammatory response deleterious to the organ involved but also to the system as a whole. Mesenteric ischemia occurs when the veins or arteries that supply blood to the intestine are obstructed. In transplants, the organ undergoes total (arterial and venous) I/R. Few available treatments exist. Greater knowledge of these conditions would aid in the search for new therapies. However, the precise nature of the response arises after venous, arterial or total ischemia is not fully understood.

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Various plant extracts were studies, amongst them curcumin, rosmarinic acid and extract of mint before ischemia (a restriction in blood supply to tissues, causing a shortage of oxygen and glucose) and during reperfusion (Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen).


Various parameters were measured like the production of reactive oxygen species (ROS).  Curcumin and extract of Mint were found to be the most effective in reducing reperfusion-induced health issues.

All plant extracts tested were found to have antioxidant properties, as demonstrated by a reduction in ROS production. This effect was confirmed in curcumin and extract of mint which reduced reperfusion injury.

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