Ginger: Inhibits Human Breast Cancer Cells (Model system)
Ginger component Zerumbone was investigated by Sehrawat et al for its anticancer efficacy against human breast cancer cells in vitro and in vivo. The results of this investigation suggest that Zerumbone causes a form of phase cell cycle arrest and apoptosis in human breast cancer cells.
Ginger is a key spice used in The Wise Herb Company infusion recipes.
Oral cancers (squamous cell carcinoma) were studied by In et al, in an attempt to find a safer and more affordable effective treatment. A component of ginger – 1’S-1′-acetoxychavicol acetate (ACA), was studied in a model cell system. ACA alone was shown to inhibit the growth of oral cancer cells, induced apoptosis and suppressed its migration rate. The effects of ACA also correlated with a down-regulation of various cancer and inflammatory biomarkers: NF-kappaB regulated gene (FasL and Bim), proinflammatory (NF-kappaB and COX-2) and proliferative (cyclin D1).
The conclusion of this investigation suggest that ACA can inhibit the growth of oral cancer and modulates the proinflammatory microenvironment.