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Immunity and The Wise Herb Company

October 18, 2012

Immune response can decline with age and we all know that when the temperatures change – going from summer to autumn or winter into spring – there is an increased susceptibility to colds and this can happen to anyone at any age.  A healthy lifestyle (good balanced diet and exercise) is always going to help but sometimes you can give your body a helping hand. Here we’ve summarised some of the recent research on the Herbs & Spices we use in our UP&GO natural infusion.

Centella asiatica (Pennywort)

Pennywort contains a series of terpenes (oils), the most common of which is called Madecassoside. Recently, Liu et al investigated a therapeutic potential and underlying mechanisms of madecassoside on induced arthritis in an animal model.

The results suggest that components of Pennywort like madecassoside can prevent induced arthritis, and this component is the major active constituent of Centella asiatica responsible for clinical uses for rheumatoid arthritis.

The underlying mechanisms of action may be through regulating the abnormal humoral and cellular immunity as well as protecting joint destruction.


Glycyrrhizin and similar components of liquorice are known to be pharmacologically active components of liquorice root.

In a study by Hardy et al, Glycyrrhizin type components were tested for their ability to inhibit rotavirus replication in cell culture. Rotavirus is the most common cause of severe diarrhea among infants and young children. The long term goal of this is to discover natural compounds that may complement existing vaccines. The results suggest that treatment with liquorice components can reduce rotavirus yields by 99% when added to infected cultures.

Green Tea

Chen et al (Archives of virology, Apr 11, 2012) showed that Green Tea Epigallocatechin-3-gallate (EGCG) inhibits the replication cycle of a virus (hepatitis C)

The inhibitory mechanisms of EGCG were attributable to the suppression of both the virus entry and RNA replication steps. Furthermore, the virus could be rapidly eliminated from cells. These data indicate that EGCG is a potential candidate as a preventive and antiviral drug for viruses – in this case Hepatitis C infection.

Also, Chen was part of a team led by Ku that investigated the pathways involved in epigallocatechin gallate (EGCG) modulation of insulin-like growth factor (IGF)-I-stimulated and IGF-II-stimulated mitogenesis in 3T3-L1 preadipocytes (forming fat cells and potential immunity function).

Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea was also shown in research by Ling et al

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