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Anti-inflammatory activities of Cinnamon Extract

December 5, 2012

Cinnamon, as we know from the pages on this website and the InnOrbit product page, is a popular ingredients for traditional medicines like Ayurveda and has various pharmacological activities which include anti-viral, and anti-cancer properties amongst others.  In a study by Hong et al the in vivo and in vitro inhibitory effect of Cinnamon water extract on induced tumor necrosis factor (TNF)-alpha and its underlying intracellular mechanisms was investigated in an animal model system.

Cinnamon extract were administrated and serum levels of TNF-alpha and interleukin (IL)-6 were determined 1 hour after Lipopolysaccharide stimulation.  Various biomarkers were assayed for viability, cytokine expression and signaling molecules upon stimulation.  Liposaccharides act as endotoxins and elicit strong immune responses in animals.


The results show that oral administration of cinnamon in an animal model system significantly decreased the serum levels of TNF-alpha and IL-6. CWE treatment in vitro decreased the mRNA expression of TNF-alpha. The scientist conclude that treatment with cinnamon extract decreased LPS-induced TNF-alpha in serum and the results indicate that the observed anti-inflammatory action of Cinnamon extract may originate from the presence of polyphenols.

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