The Most Effective Cancer Chemopreventive Polyphenol in Green Tea
Previous studies have shown, and reported on this website, that polyphenol compounds from Green Tea have anticancer benefits. In investigations by Du et al, they determined the cancer chemopreventive potentials of various polyphenols (including epigallocatechin gallate, EGCG). They studied the structure-activity relationship of10 polyphenol compounds and the effect on human colorectal cancer cells was evaluated.
Cell cycle distribution and apoptotic effects were also analyzed. The results suggest that of the 10 polyphenols, EGCG showed the highest antiproliferative effects, and significantly induced cell cycle arrest in the G1 phase and cell apoptosis.
The investigators suggest that the gallic acid group significantly enhanced catechin’s anticancer potential.
This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents.