Holy Basil leaf extract and Potential Cancer Therapy
Alternative therapies against lethal pancreatic cancer (PC) are continually being sought. Shimizu et al indentified Holy Basil (Ocimum sanctum) as a potential candidate for cancer therapy. Holy Basil has been used for thousands of years in traditional Indian medicine, but its anti-tumorigenic effect remains largely unexplored.
Extracts of Holy Basil leaves inhibit the proliferation, migration, invasion, and induce apoptosis of Pancreatic Cancer cells in vitro. The expression of genes that promote the proliferation, migration and invasion of cancerous cells including various biomarkers.
Intraperitoneal injections of the aqueous extract significantly inhibited the growth of orthotopically transplanted PC cells in vivo (p<0.05). Genes that inhibit metastasis (E-cadherin) and induce apoptosis (BAD) were significantly upregulated in an animal tumour model
In conclusion, the research suggests that leaves of Holy Basil could be a potential source of novel anticancer compounds in the future.
Holy Basil is a key ingredient used in InnOrbit natural health products.
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