EGCG from Green Tea inhibits cell proliferation (breast cancer cells)
Green Tea extract may inhibit breast cancer progression by blocking angiogenesis.
Angiogenesis is blood vessel formation. Tumor angiogenesis is the growth of new blood vessels that tumors need to grow. This process is caused by the release of chemicals by the tumor and by host cells near the tumour.
The molecular mechanisms of Green Tea are not well understood.
Epigallocatechin-3-gallate (EGCG) is the major biologically active component of green tea and was studied by Braicu et al. Various factors such as cell proliferation and relative gene expression of vascular endothelial growth factor (VEGF) expression were studied on cell lines before and after EGCG treatments.
The inhibition of cell proliferation at 72 hours suggests a possible reactivation of apoptosis.
In conclusion, the data suggest that EGCG suppresses the growth, migration and invasion of human breast cancer cells by inhibiting VEGF expression.
A better understanding of this mechanism may lead to an improved strategy for tumor therapy based on the inhibition of angiogenesis.
See also – Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol