Epigallocatechin-3-gallate from Green Tea attenuates head and neck cancer
Many head and neck cancers are believed to be initiated from and maintained by cancer stem cells. In a study by Lee et al, Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, was shown to inhibit cancer growth and induce apoptosis in various cancers, including head and neck cancers.
The investigators examined the anti-tumour effect of Green Tea EGCG on the above cancers to elucidate further its mechanism.
The studies indicated that EGCG inhibits the self-renewal capacity of head and neck squamous cancers by suppressing their sphere forming capacity, and attenuates the expression of stem cell markers.
Green Tea is a key ingredient in the herbal infusions hand crafted by The Wise Herb Company.
EGCG treatment was shown to augment cisplatin-mediated chemosensitivity.
The data suggest that EGCG in combination with cisplatin can be used for the management of the above types of cancers.