Proapoptopic, Anti-Inflammatory, Anti-Proliferative, Anti-Invasive and Anti-Angiogenic targets of essential oils in Cardamom
Cardamom (Elettaria cardamom), is known as the “Queen of Spices”. It has been traditionally used as a medicine and has shown cancer chemo-preventive potential in in vitro and in vivo systems.
The precise pharmacological nature of cardamom has still not been fully evaluated.
In a study, by Bhattacharjee et al they identified the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom’s bioactive principles (namely, eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol).
Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site.
The investigation demonstrated vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom.
Cardomom is a key ingredient of the handcrafted green tea infusions from The Wise Herb Company.