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Liquorice: Anti-insulin resistance & Diabetes

October 4, 2013

Liquorice in sweet formResults from a recent study (Li et al) suggest that Liquorice components may have  potential as new anti-insulin-resistant treatments.

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator in insulin-signaling pathways, amongst other biochemical processes.   Tyrosine phosphatase inhibitors, therefore, may have potential in chronic conditions such as diabetes and obesity

A library of licorice flavonoids allowed for the discovery of several compounds, including licoagrone, licoagrodin, licoagroaurone, and isobavachalcone, as new PTP1B inhibitors.


Liquorice compounds inhibit the activity of tyrosine phosphatase and exhibit different  activity in the insulin-signaling pathway.   The results suggest the potential of liquorice components as a new anti-insulin-resistant treatments.



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