Ginger and Cardioprotective Properties
Oxidation of low-density lipoprotein (LDL) seems to have a role in atherosclerotic plaque formation. Ginger has been shown to have antioxidants and cardioprotective properties (see also Ginger & Heart Health and Ginger: Prevention Hypertension and Cardiovascular Disease).
In a study by Gunathilake and Rupasinghe they demonstrated the antioxidant effects of extracts of ginger and major ginger constituents of human LDL. The LDL oxidation inhibition by ethanol, methanol, ethyl acetate, and hexane extracts of ginger was 71%, 76%, 67%, and 67%, respectively.
These studies indicate that the phenolic bioactives of ginger-6-gingerols, 8-gingerols, 10-gingerols, and 6-shogaol-seem to be strong inhibitors of induced LDL oxidation. Ginger extracts inhibit human LDL oxidation in vitro.
Can Ginger have a protective effect in the formation of “fatty” plaques in arteries?
“Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the major cause of morbidity and mortality from CVD (Cardiovascular Disease) in much of the world’s population. The disease involves the formation of Plaques in arterial walls that narrow the arterial passage, restricting blood flow and increasing the risk of occlusion of blood flow by a myocardial infarction. There is now a consensus that Atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall. The Oxidative Modification hypothesis predicts LDL (Low-Density Lipoproteins) oxidation as an early event in Atherosclerosis, and oxidized LDL as one of the important contributors of Atherogenesis” see LDL Oxidation in Atherogenesis.